If both of their centre halves are out then I think I'd be tempted to start leaning towards a draw not being the maximum we'd be happy with.
Alderweireld's fine apparently and resumed training the next day. Not sure about Vertonghen, but Wimmer and Dier are good alternatives for them. Ben Davies is a weakness we can exploit.
Looking at the two sides, they have a better keeper, a much better defence when everyone is fit, the midfields are pretty much on par, and they probably have a slightly more potent attack with Eriksen and Alli supporting Kane. So we'll need to perform somewhere near our best or gain a tactical advantage in my view, to have any chance.
A win or a draw would be great, but I'm not going to lose my shit if we're beaten by a very good side.