Would consider Zouma for Holgate here, as we'll have a mid-week cup game and it would be nice to not debut two new CBs (potentially) at the same time.
Pickford/Coleman, Zouma, Keane, Baines/Gueye, Davies/Walcott, Sigurdsson, Richarlison/Tosun. Get Bernard ~20 minutes late on, with a view to starting him in the cup game.
Then for the Rotherham match:
Stekelenburg/Coleman, Holgate, Mina, Digne/Gueye, Dowell/Walcott, Bernard, Lookman/Calvert-Lewin. Make some changes there but not a complete swap.