The England international fell heavily after a challenge late in the first half and had his movement restricted by the pain he suffered. Meanwhile, Ronald Koeman has confirmed that James McCarthy has suffered another injury set-back in training.
“Leighton had a problem with his back,” added Koeman.
“He couldn’t move any more and that was the reason we had to change it.
“James again has some problems with his hamstring – it happened at the beginning of last week. It’s painful for him and also for me because I like him and we want to progress with him. But every time we do that he has to take a step back. It’s not a big hamstring injury – he will be out for one or two weeks – but I’m really disappointed about it.
“We need to deal with his fitness and maybe [play him] 30-35 minutes like last week, then put him through recovery. We need to learn. I’m not a doctor but I want the best for him, it’s difficult. It’s another step back for the boy and that’s really disappointing. We need to find a solution and we haven’t found it yet.”